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Introduction to mass transfer in single-use bioreactors

Stirred-tank bioreactors were originally based on the design principles of traditional microbial fermentors, which relied heavily on stainless steel technologies. As such, the design of most sparge systems found in stirred-tank bioreactors was not intended for mammalian cell cultures. Typical microbial fermentors rely on high-shear mixers,

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ANN-CFD research on key parameters of stirred tank based …

In industrial applications, solid–liquid mixing in stirred tanks is widely used in processes such as mineral processing, crystallization, polymerization, precipitation, catalytic reactions, food processing, and water treatment (Maass et al., 2019, Liu et al., 2019, Sun et al., 2022, Shokry et al., 2020).Stirred tank design needs vary for every industrial application.

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The Shift from Batch to Continuous-Flow Reactors

Continuous-flow reactions have long been practiced in commercial operations such as petroleum refining and within many other chemical production facilities. More recently it has become common to see tubular reactors replacing or augmenting batch, stirred-tank operations being performed in the pharmaceutical and fine chemical industries, both in laboratory and …

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BioBLU ® c Single-Use Bioreactors

Single-use, stirred-tank, rigid-walled bioreactors available in sizes ranging from 100 mL to 40 L working volume; All BioBLU c bioreactor sizes available with pitched-blade impellers for cell culture applications; BioBLU 0.3sc bioreactors are designed for stem cell applications in research and development

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CFD Research on the Influence of 45° Disk Turbine Agitator …

A numerical simulation of a solid–liquid mixture concentration field in a cone-bottom stirred tank (diameter D = 150 mm) was conducted using computational fluid dynamics (CFD). The influence of the 45° disk turbine impeller diameter on the mixing time number of solid–liquid mixture, mixing energy per unit volume, concentration standard deviation, …

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Solid-liquid flow in stirred tanks: "CFD-grade" experimental

Stirred tanks are commonly used to suspend solid particles in a liquid in many branches of industry such as chemical engineering (Sardeshpande and Ranade, 2012), biotechnology (Trad et al., 2015) and minerals processing (Wu et al., 2011).Typical applications are heterogeneously catalyzed reactions, the production of bio-hydrogen, and separation by …

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Design and Performance of Single-Use, Stirred-Tank …

Figure 3: Allegro STR 200 System features. Ergonomics of Biocontainer Handling and Protection (Figure 3): Flexible polymeric biocontainer film for single-use used in constructing a stirred-tank bioreactor can be damaged during manufacturing through final installation and operation. Thus, Pall paid special attention to features such as biocontainer geometry, …

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Sebigas CSTR Technology :BiogasWorld

CSTR (or Continuous-flow Stirred Tank Reactor) is a technology based on a semi-continuous flow of fresh biomass that enters the reactors, mixed at controlled temperature, and exits as biogas and digestate. Home / Anaerobic Digestion / Liquid digestion systems / Sebigas CSTR Technology. Contact Sebigas.

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Stirred Tank Design

Impeller: Impellers are the heart of the Stirred Tank. Impeller selection and design are the most critical design elements. Impellers are selected to meet the process requirements. The selection is also guided by the viscosity of the fluid and the number and nature of the phases involved.

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Stem Cell Derived Exosome Production in Stirred-Tank …

Mongolia Montenegro Montserrat Morocco Mozambique ... Stirred-tank bioreactors offer the possibility to tightly control and monitor the production of exosomes, as well as the scalability, to produce increasing amounts. However, the cultivation of stem cells in stirred-tank bioreactors requires profound knowledge and precise control of the ...

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Impeller shape-optimization of stirred-tank reactor: CFD …

Therefore, the stirred-tank reactor is equipped with a rotating component to increase the mass transfer rates and homogeneity of the fluid inside the reactor [5]. Design and selection of the rotating parts of the stirred-tank reactor play a vital role in the mixing process [6]. To design the stirred-tank reactor equipped with impeller ...

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Scalable Stirred-Tank Bioreactor-Mediated Manufacturing …

Upstream manufacturing steps of T cell activation and expansion are done in-vessel, in a stirred-tank bioreactor. T cell selection, which is necessary for CAR-T-based therapy, is done in the bioreactor itself, thus maintaining optimal culture conditions through the selection step. Platform's attributes of automation and performing the steps of ...

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I. Stirred Tank Reactor

ChE 512 – Chapter 6 Spring 2005 5 FIGURE 4: Power number as a function of Reynolds number for baffled and unbaffled stirred tanks. fully baffled unbaffled Np 100 10 0 0.1 1 10 100 1,000 10,000 105 106 Re Np Critical Reynolds number for transition from laminar to turbulent mixing is ill defined and lies in the

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Study on gas–liquid flow characteristics in stirred tank with …

The gas–liquid stirred equipment consists of a cylindrical tank (dia. T s = 420 mm) with a standard ellipsoidal head at the bottom of tank, as shown in Fig. 3.Four equally spaced baffles (width: w = T s /10, height: h b = 400 mm) were fitted in the tank, The clearance from baffle to the tank wall is 2 mm. Tap water (density: ρ l = 998.2 kg·m −3, dynamic viscosity: μ l = 1 × …

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Gas–Liquid Mixability Study in a Jet-Stirred Tank for Mineral …

Micro- and nano-bubble jet stirring, as an emerging technology, shows great potential in complex mineral sorting. Flow field characteristics and structural parameters of the gas–liquid two-phase system can lead to uneven bubble distribution inside the reaction vessel. Gas–liquid mixing uniformity is crucial for evaluating stirring effects, as increasing the contact …

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Chemical Reactor Teaching Equipment

– Continuous Stirred Tank Reactor – Tubular Reactor – Transparent Batch Reactor – Plug flow reactor – Laminar Flow reactor. Fully computer controlled and supplied with educational software (32/64 bit) specific to each reactor type. …

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