Mechanical Activation by Ball Milling as a Strategy to …
1. Introduction. Almost half of the oral administered commercial drugs have low solubility, which affects their bioavailability [1,2].Several alternatives to modify the supramolecular structure of APIs have been proposed to overcome their low solubility; these strategies include amorphization [3,4,5], solid dispersion [6,7,8,9], preparation of co-crystals [10,11], and …
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